Tumorsuppresor genes

Genetics + genomics > Clinical/medical genetics > Disease related (typology of disorder) > Cancer genetics > Growth regulation > Tumorsuppresor genes
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The course deals with the role of mitochondria in cancer development and progression. Bioenergetics of cancer, mitochondrial genetics and mitochondria-related signalling pathways are discussed in detail, as well as mitochondria-related aspects of cancer research such as aging, bioinformatics and mit ...
Both succinate dehydrogenase (SDH) and fumarate hydratase (FH) are TCA cycle enzymes that convert succinate to fumarate and fumarate to malate, respectively. SDH is also a functional member (complex II) of the Electron Transport Chain (ETC). Surprisingly, although SDH and FH are „housekeeping gene ...
Germline mutations in the Fumarate Hydratase (FH, also known as fumarase) predispose to Hereditary Leiomyomatosis and Renal Cell Carcinoma (HLRCC), a tumor syndrome in which mutation carriers are at risk for developing cutaneous and uterine leiomyomas and an aggressive form of kidney cancer. Fumarat ...
Cancer is always a genetic disease, as it results from genetic defects in cells. In the majority of cases, the accumulation of genetic changes in a tissue is random, and the tumour is termed sporadic. In a fraction of cases, however, all the cells of the body carry an inborn genetic defect, which in ...
Zvýšené riziko malignit u heterozygotů v rodinách pacientů s Nijmegen breakage syndromem Autoři: Seemanová E., 1Jarolím P., 2Seeman P., 3Varon R., 3Sperling K. Autoři - působiště: Oddělení klinické genetiky, Ústav biologie a lékařské genetiky 2. LF UK, Praha 1Ústav hematolog ...