Mitochondrial DNA

Genetics + genomics > Molecular genetics > Studies of DNA > Mitochondrial DNA
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The course deals with the role of mitochondria in cancer development and progression. Bioenergetics of cancer, mitochondrial genetics and mitochondria-related signalling pathways are discussed in detail, as well as mitochondria-related aspects of cancer research such as aging, bioinformatics and mit ...
This is the closuring lecture of the course in Mitochondrial Metabolism and Cancer on how bioenergetics has helped progress in cell biology and human pathology, milestone discoveries regarding mitochondrial research are presented.
In this course, we discuss the concept of variable metabolic remodeling and signaling in tumors, specifically the modifications in the main biochemical energy pathways observed in cultured cancer cells and excised tumors, as well as the concentration changes in various (onco)metabolites that partici ...
Complex cellular functions are often determined by the dynamic interactions occurring in networks of hundreds or thousands gene products that generate system-level properties largely unpredictable considering only the behaviour of individual nodes of the network. The phenotype of “in vitro” grow ...
Both succinate dehydrogenase (SDH) and fumarate hydratase (FH) are TCA cycle enzymes that convert succinate to fumarate and fumarate to malate, respectively. SDH is also a functional member (complex II) of the Electron Transport Chain (ETC). Surprisingly, although SDH and FH are „housekeeping gene ...