Growth regulation

Genetics + genomics > Clinical/medical genetics > Disease related (typology of disorder) > Cancer genetics > Growth regulation
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Video: 46
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The course deals with the role of mitochondria in cancer development and progression. Bioenergetics of cancer, mitochondrial genetics and mitochondria-related signalling pathways are discussed in detail, as well as mitochondria-related aspects of cancer research such as aging, bioinformatics and mit ...
Complex cellular functions are often determined by the dynamic interactions occurring in networks of hundreds or thousands gene products that generate system-level properties largely unpredictable considering only the behaviour of individual nodes of the network. The phenotype of “in vitro” grow ...
Both succinate dehydrogenase (SDH) and fumarate hydratase (FH) are TCA cycle enzymes that convert succinate to fumarate and fumarate to malate, respectively. SDH is also a functional member (complex II) of the Electron Transport Chain (ETC). Surprisingly, although SDH and FH are „housekeeping gene ...
Germline mutations in the Fumarate Hydratase (FH, also known as fumarase) predispose to Hereditary Leiomyomatosis and Renal Cell Carcinoma (HLRCC), a tumor syndrome in which mutation carriers are at risk for developing cutaneous and uterine leiomyomas and an aggressive form of kidney cancer. Fumarat ...
Gluscose is required for growing cells and therefore the increased vascular density of proliferating tissues serves their high glucose demand. This lecture will describe the particular metabolic pathways activated in growth and in tumors cells, that aim at directing nutrient s for biosynthesis, for ...