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The advent of next-generation sequencing technologies is revolutionizing genetic research. Their Important applications range from genome sequencing, ChIP-seq to transcriptome analysis and small RNA discovery. Here, I will give an introduction to Illumina/Solexa sequencing platform and discuss its p ...
New-generation genome sequencing technologies recently introduced in tne market have the potential to revolutionize the field of genomics. These new technologies are based on sequencing-by-hybridization [1], sequencing-by-ligation [2] or sequencing-by-synthesis [3,4]. The latter methodology, seque ...
New-generation genome sequencing technologies recently introduced in tne market have the potential to revolutionize the field of genomics. These new technologies are based on sequencing-by-hybridization [1], sequencing-by-ligation [2] or sequencing-by-synthesis [3,4]. The latter methodology, seque ...
I will present novel array approaches to screen whole SC genomes with increased sensitivity and specificity for chromosomal imbalances: (1) averaging intensity ratios across chromosomes enables accurate detection of aneuploidies, (2) likelihood estimation for copy number variations (CNV) using arra ...
The rapid advance of the Human Genome Project has lead to the identification the 30,000-35,000 genes that make up our genetic complement. The combination of this sequence information and advances in microarray technology has opened up the possibility of highly parallel genome-wide investigations of ...
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