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Bone marrow derived monocyte/macrophage precursor cells develop into osteoclasts through cell-cell interactions with mesenchymal cells, including osteoblasts. The cross talk between these two main bone cell components results in a dynamic process, called bone remodeling, crucial for maintaining bone ...
Cell-cell interactions are critical to the development of organs and organisms. They involve a limited number of signalling pathways. BMP signalling molecules (a subclass of the TGFß superfamily) constitute a major one. Over the last years, this pathway has been well documented, from the synthesis ...
Mesenchymal stem cells in bone development
Bone is known, among the many tissues in human body, as one with the highest potential for regeneration. Heterotopic ossification (HO) consists in abnormal formation of mature bone in soft tissues. Different etiologies of HO are recognized, traumatic, neurogenic and genetic, the last of which will b ...
Shortening of digits due to abnormal development of phalanges or metacarpals/metatarsals. It can be isolated, part of a skeletal dysplasia or part of a syndrome. There are 421 brachydactyly hits in LMD.
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