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Massive Pyrosequencing - workshop
Increasing attention has been paid in the last years to the functional relevance of 3D genome organisation in the nucleus as an epigenetic mechanism of gene regulation beyond regulatory sequences and local chromatin configuration. This concerns e.g. the positioning of genome loci with regard to a sp ...
The availability of a reference human DNA sequence and high throughput technologies such as automated DNA sequencing has made the identification of sequence variations a key tool in several fields of modern biology. Resequencing of large sets of clinically relevant genes, in order to identify varian ...
It has been estimated that only 1.2 % of the human genome encodes proteins, however 60-70% of the mammalian genome is transcribed on one or both strands into non-protein coding RNAs 1. The untranslated fraction includes, among other small non-coding (snc)RNAs, the broad class of evolutionarily conse ...
Despite considerable progress in the field of high throughput sequencing, decoding the whole genome of a human being in one experiment is still not possible. However, this current lack of capacity has not derogated the appeal of the technique for human geneticists. There are several applications, wh ...
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