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Studies into the influence of consanguinity on intellectual performance have produced quite varied results. In a small-scale USA study no significant effect was observed with respect to mean IQ but there was a significantly higher standard deviation in the IQ scores of first cousin progeny, which ra ...
Current biomedical research is experiencing a large boost in the amount of data generated. Individual genomes are being characterized at increased level of details using single nucleotide polymorphism (SNP) arrays, and, more recently, exome and whole-genome re-sequencing (WGRS). At the same time, te ...
Taybi-Linder syndrome/MOPD1 [OMIM 210710] is a rare recessive disorder characterized by brain and bone malformations and unexplained postnatal death. Only a small sample of patients without well-characterized consanguinity was available for study. Because genealogical information was unreliable, th ...
Current biomedical research is experiencing a large boost in the amount of data generated. Individual genomes are being characterized at increased level of details using single nucleotide polymorphism (SNP) arrays, and, more recently, exome and whole-genome re-sequencing (WGRS). At the same time, te ...
Genome-Wide Association Studies (GWAS) is a powerful tool for identifying loci involved in the control of complex traits. In most GWAS, study participants are assumed to be unrelated and coming from a single population. However, even for carefully designed studies, some degree of relatedness and pop ...
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