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Germline mutations in the Fumarate Hydratase (FH, also known as fumarase) predispose to Hereditary Leiomyomatosis and Renal Cell Carcinoma (HLRCC), a tumor syndrome in which mutation carriers are at risk for developing cutaneous and uterine leiomyomas and an aggressive form of kidney cancer. Fumarat ...
Thanks to the absence of recombinatory events and repair enzymes, mitochondrial DNA is the marker of excellence when the interest is to study human population genetics. Moreover, being mitochondrion the powerhouse of the cell, any mutation involving both mitochondrial DNA and nuclear DNA regions whe ...
The mitochondria as “the aging clock” were proposed in 1972 by Harman. The theory was based on the fact that ROS (Reactive Oxygen Species) are, in physiological conditions, by-products of the OXPHOS (oxidative phosporylation) process which occurs in mitochondria. There is good agreement, today, ...
Gluscose is required for growing cells and therefore the increased vascular density of proliferating tissues serves their high glucose demand. This lecture will describe the particular metabolic pathways activated in growth and in tumors cells, that aim at directing nutrient s for biosynthesis, for ...
The collection of samples from HIV-infected patients is the beginning of the chain of translational research. To carry out quality research that could eventually end in a personalized treatment for HIV, it is essential to guarantee the availability, quality and traceability of samples, under a stric ...
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