Latest resources

Classical studies of consanguinity have taken advantage of the relationship between the gene frequency for a rare autosomal recessive disorder (q) and the proportion of offspring of consanguineous couples who are affected with the same disorder. We developed a new approach for estimating q using mut ...
Two individuals are (biologically) related if they share a common ancestor. In that case they may have derived regions of their chromosomes from a common ancestral chromosomes and thus they will, in the absence of mutations, have the same genetic material across these regions. We begin by consideri ...
Close kin relationships have a long history in human populations, as evidenced in modern Western societies by the genomic evidence of extensive runs of homozygosity (ROH) resulting from consanguineous unions in much earlier generations. Estimates of the numbers of mature adults who took part in the ...
People tend to see genetics as raising uniquely sensitive ethical issues. Whether that view is right or wrong, it does mean that as working geneticists we have to be specially sensitive to the ethical implications of our work. Although we all subscribe to general principles of ethical conduct, somet ...
Recent studies have indicated that humans have an exceptionally high per-generation mutation rate of 7.6 x 10-9 to 2.2 x 10-8. These spontaneous germline mutations can have serious phenotypic consequences when affecting functionally relevant bases in the genome. In fact, their occurrence may explain ...
sfy39587f01