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This resource contains materials from an advanced course in the field of statistical genetics. It covers a large spectrum of themes from basic statistics/genetics, with lectures dedicated to population genetics and genetic epidemiology, to the most recent advancements in association studies and lin ...
This lecture follows an earlier introduction to parametric linkage analysis using lod scores. Heterogeneity is described assuming rare major genes.
This ia a basic introduction to consanguinity and its impact. The following topics are covered : - definition of consanguinity - measure of consanguinity at the individual and population level - impact of consanguinity on trait prevalence - interest for mapping genetic disorders
Basic overview of genetic epidemiology How to show the existence of a genetic component for a disease ? How to characterize it ? Principles of segregation analysis How to locate the genes responsible for this component ? Principles of parametric and non parametric linkage and association strategi ...
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