Genetic Counseling: Cancer Genetics

Submitted: Monday 26th of July 2010 06:26:21 PM
Submitted by: egf
Language: English
Educational levels: qc1, qc2, qc3

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Abstract

This resource contains materials from advanced courses of Genetic Counseling. It is especially focused on cancer genetics.

Resources

Introduction to cancer genetics D. Turchetti Cancer is always a genetic disease, as it results from genetic defects in cells. In the majority of cases, the accumulation of genetic changes in a tissue is random, and the tumour is termed sporadic. In a fraction of cases, however, all the cells of ...
Hereditary predisposition to cancer is a relatively new area of clinical practice. Although recognised and documented in the medical literature for centuries, clinical services aimed at addressing genetic risk to cancer have emerged only in the few decades. The principle aim of clinical genetics s ...
Familial cancer counselling scenarios
Hereditary predisposition to cancer is a relatively new area of clinical practice. Although recognised and documented in the medical literature for centuries, clinical services aimed at addressing genetic risk to cancer have emerged only in the few decades. The principle aim of clinical genetics s ...
Several statistical models exist in the literature which estimate the probability of developing cancer or the probability of being a carrier of a high risk susceptibility gene. Such models have several applications such as identifying individuals at high risk of developing cancer, they can be used f ...
Several statistical models exist in the literature which estimate the probability of developing cancer or the probability of being a carrier of a high risk susceptibility gene. Such models have several applications such as identifying individuals at high risk of developing cancer, they can be used f ...
Hereditary colorectal cancer accounts for up to 5 % of all colorectal cancers. A variety of known and unknown genes are responsible for the two established phenotypes. Familial adenomatous polyposis coli (FAP) is phenotypically characterized by hundreds or even thousands of polyps in the colon and r ...
Issues in Genetic Counselling: Ethical, Social, and Legal Issues in Cancer Genetic Testing.
Hereditary forms of cancer are due to gene mutations identified in the nineties. Estimation of risks associated with pathogenic mutations requires appropriate methods because of ascertainment on multiple case families. Guidelines for genetic testing and medical management are available for breast-ov ...
Principles of cancer treatment • Remove primary – surgery • Reduce recurrence risk, improve survival – Adjuvant therapies • May need to consider future risks of new primary – Primary risk reducing strategies

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Keywords

abnormal, adenomatous polyposis coli, affected, allele, allele frequency, Analysis of the entire coding region: Mutation scanning, Analysis of the entire coding region: Sequence analysis, ascertainment, association, autosomal dominant, autosomal recessive, base, base pair, bias of ascertainment, biomarker, BRCA, cancer family syndrome, cancer genetics, Cancer Treatment, carrier, carrier rate, case-control, cell, cell cycle, cell line, chi-square, chromatid, chromosome, clinical genetics, codominant, cohort, colectomy, colonoscopy, competent, concordance, congenital hypertrophy of the retinal pigment epithelium, correlation, deletion, deoxyribonucleic acid, dna polymerase, dna repair, dominant, dominant gene, electrophoresis, environmental factor, ER, excision, exon, expression, familial, familial adenomatous polyposis, familial relative risk, familial risk, family history, frequency, gene, gene expression, genetic counselling, genetic predisposition, genetics, genomic dna, genotype, genotypic relative risk, germ line mutation, germline, gm, helicase, hereditary, hereditary non-polyposis colorectal cancer, heredity, heterogeneity, heterogeneous, heterozygote, homozygous, immunohistochemistry, incidence, index case, informed consent, inheritance, intron, isolated, kilobase, ligase, ligation, linkage, linkage analysis, linkage disequilibrium, locus, marker, mastectomy, maternal, mendelian inheritance, messenger rna, microsatellite, microsatellite instability, mismatch repair mechanism, missense mutation, mitosis, mode of inheritance, molecular genetic testing, mutant, mutation, negative predictive value, oncogene, pathogenic mutation, pedigree, penetrance, phenotype, polygenic, polymerase chain reaction, polymorphism, polyp, population, population risk, positive predictive value, predisposing mutation, predisposition, prevalence, primer, probability, proband, probe, prophylactic, prophylactic surgery, prostate, protein, protein expression, rearrangement, recessive, recessive gene, recurrence risk, regression, relative risk, replication, replication fork, retina, risk assessment, risk estimates, screening, segregation, segregation analysis, selection, sensitivity, sequence, somatic, specificity, sporadic, survival, syndrome, synthesis, trait, unaffected, undifferentiated, uterus, variation, wildtype

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