Cytogenetics: next generation approaches

Submitted: Wednesday 4th of August 2010 05:23:03 PM
Submitted by: egf
Language: English
Educational levels: expert, qc1, qc2, qc3

Abstract

This resource contains materials from advanced courses of cytogenetics and it is especially focused on next generation approaches.

Resources

The availability of a reference human DNA sequence and high throughput technologies such as automated DNA sequencing has made the identification of sequence variations a key tool in several fields of modern biology. Resequencing of large sets of clinically relevant genes, in order to identify varian ...
The availability of a reference human DNA sequence and high throughput technologies such as automated DNA sequencing has made the identification of sequence variations a key tool in several fields of modern biology. Resequencing of large sets of clinically relevant genes, in order to identify varian ...
New-generation genome sequencing technologies recently introduced in tne market have the potential to revolutionize the field of genomics. These new technologies are based on sequencing-by-hybridization [1], sequencing-by-ligation [2] or sequencing-by-synthesis [3,4]. The latter methodology, seque ...
Despite considerable progress in the field of high throughput sequencing, decoding the whole genome of a human being in one experiment is still not possible. However, this current lack of capacity has not derogated the appeal of the technique for human geneticists. There are several applications, wh ...
Lecture "Expression profiling by next generation sequencing: a comparison with microarrays" discussing the difference between techniques for gene expression profiling with the subjects SAGE, microarray, tag-based assays and Solexa sequencing.
The advent of next-generation sequencing technologies is revolutionising genetic research. Their Important applications range from genome sequencing, ChIP-seq to transcriptome analysis and small RNA discovery. Here, I will give an introduction to Illumina/Solexa sequencing platform and discuss its ...
It has been estimated that only 1.2 % of the human genome encodes proteins, however 60-70% of the mammalian genome is transcribed on one or both strands into non-protein coding RNAs 1. The untranslated fraction includes, among other small non-coding (snc)RNAs, the broad class of evolutionarily conse ...
It has been estimated that only 1.2 % of the human genome encodes proteins, however 60-70% of the mammalian genome is transcribed on one or both strands into non-protein coding RNAs 1. The untranslated fraction includes, among other small non-coding (snc)RNAs, the broad class of evolutionarily conse ...

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Keywords

adenosine triphosphate, algorithm, Analysis of the entire coding region: Mutation scanning, Analysis of the entire coding region: Sequence analysis, annealing, antigen binding fragment, Array genomic hybridization, association, bacterial artificial chromosome, balanced translocation, base, base pair, bioinformatics, BRCA, cell, centimorgan, chi-square, chromosome, clone, cloning, coding region, coding sequence, Complementary DNA, correlation, cosmid, cytogenetics, cytoplasm, de novo, deletion, deoxyribonucleic acid, derivative chromosome, dna library, dystrophin, embryo, embryonic stem cell, enhancer, enzyme, ER, exon, expressed gene, expression, fluorescent in situ hybridization, frequency, gene, gene expression, genetics, genome, genomic dna, genomics, heterozygous, high throughput, hybridization, inversion, isoforms, karyotype, kilobase, library, ligase, ligation, linkage, locus, marker, messenger rna, methylation, microarray, microdeletion, microrna, microsatellite, mitochondrial dna, molecular genetics, mutation, northern blot, nucleotide, nucleus, oligonucleotide, open reading frame, phase, polymerase chain reaction, power, primer, probe, processing, protein, quantitative PCR, rearrangement, repetitive dna, response element, reverse transriptase pcr, ribonucleic acid, selection, sensitivity, sequence, single nucleotide polymorphism, Southern blot, specie, synthesis, threshold, transcript, transcription, translation, untranslated region, variant, variation, virus

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