Course in Mitochondrial Metabolism and Cancer (3-6 November, 2010)

Submitted: Thursday 31st of March 2011 12:45:56 PM
Submitted by: egf
Language: English
Educational levels: expert, qc3

Abstract

The course deals with the role of mitochondria in cancer development and progression. Bioenergetics of cancer, mitochondrial genetics and mitochondria-related signalling pathways are discussed in detail, as well as mitochondria-related aspects of cancer research such as aging, bioinformatics and mitochondrial gene therapy.

Resources

Cancer is a heterogeneous and complex genetic disease that drives the progressive transformation of normal cells into malignancy by a multistep ordered process. However, and in addition to the contribution of genetic mutations in the well established cancer genes (oncogenes and tumour suppressors), ...
In this course, we discuss the concept of variable metabolic remodeling and signaling in tumors, specifically the modifications in the main biochemical energy pathways observed in cultured cancer cells and excised tumors, as well as the concentration changes in various (onco)metabolites that partici ...
Both succinate dehydrogenase (SDH) and fumarate hydratase (FH) are TCA cycle enzymes that convert succinate to fumarate and fumarate to malate, respectively. SDH is also a functional member (complex II) of the Electron Transport Chain (ETC). Surprisingly, although SDH and FH are „housekeeping gene ...
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Reactive oxygen species (ROS), as generated by mitochondria during respiration, induce oxidative stress, which accumulates over life and is considered the proximal mechanism of aging and a major determinant of degenerative disease, including cancer, and lifespan (the free radical or mitochondrial th ...
Germline mutations in the Fumarate Hydratase (FH, also known as fumarase) predispose to Hereditary Leiomyomatosis and Renal Cell Carcinoma (HLRCC), a tumor syndrome in which mutation carriers are at risk for developing cutaneous and uterine leiomyomas and an aggressive form of kidney cancer. Fumarat ...
Complex cellular functions are often determined by the dynamic interactions occurring in networks of hundreds or thousands gene products that generate system-level properties largely unpredictable considering only the behaviour of individual nodes of the network. The phenotype of “in vitro” grow ...
The mitochondria as “the aging clock” were proposed in 1972 by Harman. The theory was based on the fact that ROS (Reactive Oxygen Species) are, in physiological conditions, by-products of the OXPHOS (oxidative phosporylation) process which occurs in mitochondria. There is good agreement, today, ...
Thanks to the absence of recombinatory events and repair enzymes, mitochondrial DNA is the marker of excellence when the interest is to study human population genetics. Moreover, being mitochondrion the powerhouse of the cell, any mutation involving both mitochondrial DNA and nuclear DNA regions whe ...
This is the closuring lecture of the course in Mitochondrial Metabolism and Cancer on how bioenergetics has helped progress in cell biology and human pathology, milestone discoveries regarding mitochondrial research are presented.

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Keywords

adenomatous polyposis coli, adenosine triphosphate, affected, agarose gel, algorithm, allele, amino acid, Analysis of the entire coding region: Mutation scanning, Analysis of the entire coding region: Sequence analysis, apoptosis, autosomal dominant, band, base, base pair, bioinformatics, biosynthesis, biotechnology, blastocyst, cancer genetics, carrier, cell, cell culture, cell cycle, cell division, cell line, centimorgan, chimera, chromosome, clone, cloning, coupling, cytoplasm, cytosol, daughter cell, deletion, deoxyribonucleic acid, dna repair, domain, dominant, drift, duplication, electrophoresis, embryo, enzyme, ER, expansion, expression, familial, fibroblast, fitness, fixed, frameshift, frequency, gastrulation, gene, gene expression, gene product, genetic disease, genetics, genome, genotype, germ line mutation, germline, gm, growth factor, haem, haplotype, hereditary, heterozygous, histone acetylation, homozygous, hormone, hybrid, in situ hybridization, in vitro, in vivo, incidence, informative, inherited, insertion, isoforms, isolated, kilobase, lethal mutation, linkage, linkage disequilibrium, long interspersed nuclear element, loss of function mutation, marker, maternal, messenger rna, metabolism, metastasis, microarray, mitochondria, mitochondrial dna, mitochondrion, mosaic, mutant, mutation, mutation rate, new mutation, nucleotide, nucleus, oncogene, oncogenic, origins of replication, pathogenic mutation, penetrance, peptide, phase, phenotype, point mutation, polymerase, polymerase chain reaction, polymorphism, population, predisposition, probe, promoter, prostate, protein, protein truncation test, proto-oncogene, quantitative, radiation absorbed dose, recessive, recombinant, regression, replication, replication error, replication fork, restriction enzyme, retina, ribonucleic acid, ribose, ribosomal RNA, ribosome, rna processing, screening, segregation, selection, sensitivity, sequence, somatic, somatic mutation, Southern blot, specie, specificity, sporadic, stem cell, survival, syndrome, synonymous mutation, synthesis, threshold, trait, transcription, transfer rna, transformation, transition, translation, transversion, tumor suppressor gene, untranslated region, uterus, variation, vector

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