2nd Course in The integration of cytogenetics, microarrays and massive sequencing in biomedical and clinical research - E

Submitted: Monday 4th of October 2010 07:32:00 AM
Submitted by: egf
Language: English
Educational levels: expert, qc3

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Abstract

Part E of the 2nd Course in The integration of cytogenetics, microarrays and massive sequencing in biomedical and clinical research

Resources

In mammalian cells DNA is packaged with histone proteins to form chromatin – a macromolecular assembly. Most nuclear processes including DNA transcription, replication and repair occur in this chromatin environment and are influenced by the packaging of the chromatin fibre. We have a good knowledg ...
The widespread use of array–comparative genomic hybridization (array-CGH) for the detection of copy number variants (CNVs) in both research and clinical laboratories has created a renaissance in the field of molecular cytogenetics, revealing that the human genome contains both a wealth of structur ...
Increasing attention has been paid in the last years to the functional relevance of 3D genome organisation in the nucleus as an epigenetic mechanism of gene regulation beyond regulatory sequences and local chromatin configuration. This concerns e.g. the positioning of genome loci with regard to a sp ...

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