2nd Course in The integration of cytogenetics, microarrays and massive sequencing in biomedical and clinical research - D

Submitted: Monday 4th of October 2010 07:28:42 AM
Submitted by: egf
Language: English
Educational levels: expert, qc3

Abstract

Part D of the 2nd Course in The integration of cytogenetics, microarrays and massive sequencing in biomedical and clinical research

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The advent of next-generation sequencing technologies is revolutionizing genetic research. Their Important applications range from genome sequencing, ChIP-seq to transcriptome analysis and small RNA discovery. Here, I will give an introduction to Illumina/Solexa sequencing platform and discuss its p ...
Despite considerable progress in the field of high throughput sequencing, decoding the whole genome of a human being in one experiment is still not possible. However, this current lack of capacity has not derogated the appeal of the technique for human geneticists. There are several applications, wh ...
It has been estimated that only 1.2 % of the human genome encodes proteins, however 60-70% of the mammalian genome is transcribed on one or both strands into non-protein coding RNAs 1. The untranslated fraction includes, among other small non-coding (snc)RNAs, the broad class of evolutionarily conse ...

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